Gastro-Intestinal Cancer

The UCT Mainz Program Gastro-Intestinal (GI) Cancer is based on a close collaboration between medical oncology, visceral surgery and radiooncology. In 2018, 178 surgeries for esophageal or gastric cancer, 146 liver resections for colorectal metastases as well as surgeries for 75 hepatobiliary, 76 pancreatic cancer and 207 colorectal cancer patients were performed. Within the UCT Mainz GI-oncology outpatient unit, more than 320 GI-cancer patients were newly diagnosed and treated.

Clinical Research

Clinical research activities involve the participation in >20 international research or AIO/EORTC studies, particularly in advanced esophago-gastric cancer, (     Moehler M., et al. Lancet. 2019). The clinical program is complemented by participation as national or international principal investigators in innovative immunotherapy studies (Moehler M., et al. Ann Oncol. 2018; Moehler M., et al. Oncoimmunology. 2019).

Translational Projects

Core projects in translational research include active participation in EORTC trials (EORTC 1607; 1741 and 1714) as well as the pre-clinical development of novel molecular GSK-3β inhibitors (M. Moehler; Patents EP09179986.6; EP09179984.1; EP10196865.9). In collaboration with TRON, the double- blinded randomized phase II "Muc1 vaccination after resection of colorectal liver metastases" was performed and a multicenter phase II study was initiated to investigate the effect of autologous dendritic cells vaccine and pembrolizumab in patients with colorectal cancer. Within the European consortium Horizon 2020, the multinational ONCORELIEF Project for innovative digital devices for surveillance of GI cancer and AML patients has been approved recently. Additionally, we currently evaluate a postoperative surveillance program in a Rhineland-Palatine-wide consortium with digital questionnaires for patient-related outcomes (PRO) for early diagnosis of recurrence.

Most significant publications since 2015