Doctoral thesis at the Department of Immunology, University Medical Center, Mainz University
1997 - 2003
Biology (Diploma), Johannes Gutenberg University Mainz, Germany, E. Schmitt
Scientific Degrees
PhD thesis
Dr. rer. nat. ("magna cum laude"), Institute for Immunology, Johannes Gutenberg University Mainz, 2006, E. Schmitt
Professional Career
2019 - present
Director at the Institute for Immunology, University Medical Center, Johannes Gutenberg-University Mainz
2012 - 2018
W2 Professor for Molecular Immunology, Institute for Immunology, Johannes Gutenberg University Mainz
2008 - 2011
Groupleader, Institute for Immunology, Johannes Gutenberg University Mainz, Prof. H. Schild
2006 - 2008
Postdoctoral Fellow, Institute for Immunology, Johannes Gutenberg University Mainz, Prof. E. Schmitt
Honours and Other Activities
2018
DKTK (German Cancer Consortium) Faculty Member
2017
Co-Speaker of the CRC SFB1292
Member of the committee for science and research promotion of the University Medical Center Mainz
Member of the committee for habilitation and junior development of the University Medical Center Mainz
Speaker and coordinator of the "Forschungszentrum für Immuntherapie" (FZI) at the University Medical Center of the Johannes Gutenberg University Mainz
Expert committee member Elite Network of Bavaria
Speaker of the UCT/CCC section "Cancer Immunotherapy"
2016
Member of the Steering Committee of the "Forschungszentrum für Immuntherapie" (FZI) at the University Medical Center of the Johannes Gutenberg University Mainz
Member of the NOVARTIS Advisory Board for Immunology
Faculty member of the German Immuneregulation Meeting
Member of the advisory board of the Comprehensive Cancer Center Mainz
2014
Member of the Teaching committee of the "Forschungszentrum für Immuntherapie" (FZI) at the University Medical Center of the Johannes Gutenberg University Mainz
2013
Elected Spokesman of the Section "T cells: Subpopulations and Functions" within the German Society for Immunology (DGfI)
Speaker of the Members of the "Mainz Research School of Translational Biomedicine" (TRANSMED)
2012
Member of the PhD Thesis Evaluation committee at the University of Oslo, Norway
Auswahlsymposium zum "Paul Ehrlich- und Ludwig Darmstaedter-Nachwuchspreis"
2010
"Fritz und Ursula Melchers Award" of the DGfI
Administration of animal experiments (according to FELASA C)
2008 - present
Referee for international scientific journals (Cell, Nature Reviews Immunology, Nature Immunology, Immunity, EMBO, JEM, JCI, JACI, TII, Blood, etc.)
2008
Founding member of the "Forschungszentrum für Immuntherapie" (FZI) at the University Medical Center of the Johannes Gutenberg University Mainz
Boehringer Ingelheim Award
2007 - 2009
Promotion by the Carl-Zeiss-Foundation
Selected Publications
Bohn T, Rapp S, Luther N, Klein M, Bruehl TJ, Kojima N, Aranda Lopez P, Hahlbrock J, Muth S, Endo S, Pektor S, Brand A, Renner K, Popp V, Gerlach K, Vogel D, Lueckel C, Arnold-Schild D, Pouyssegur J, Kreutz M, Huber M, Koenig J, Weigmann B, Probst HC, von Stebut E, Becker C, Schild H, Schmitt E, and Bopp T. (2018) Tumor immunoevasion via acidosis dependent induction of regulatory tumor-associated macrophages. Nature Immunology in press.
Ulges A*, Witsch EJ*, Pramanik G, Klein M, Birkner K, Bühler U, Wasser B, LuessiF, Stergiou N, Dietzen S, Brühl TJ, Bohn T, Bündgen G, Kunz H, Waisman A, Schild H, Schmitt E, Zipp F$, Bopp T$ (2016). Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development. Proc Natl Acad Sci U S A. 113: 10145-50.
Paterka M, Siffrin V, Voss JO, Werr J, Hoppmann N, Gollan R, Belikan P, Bruttger J, Birkenstock J, Jung S, Esplugues E, Yogev N, Flavell RA, Bopp T, Zipp F. (2016) Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation. EMBO J. 35(1):89-101.
Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Brühl T-J, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reißig S, Haben I, Zipp F, Waisman A, Probst HC, Beilhack A, Buchou T, Filhol-Cochet O, Boldyreff B, Breloer M, Jonuleit H, Schild H, Schmitt E, Bopp T (2015) Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. Nat. Immunol. 16: 267–275
Schmitt E, Klein M & Bopp T (2013) Th9 cells, new players in adaptive immunity. Trends Immunol. 48: 115–125
Schmitt E, Bopp T. (2012) Amazing IL-9: revealing a new function for an "old" cytokine. J Clin Invest. 122(11):3857-9.
Vaeth M*, Gogishvili T*, Bopp T*, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, Hünig T, Serfling E & Bodor J (2011) Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proceedings of the National Academy of Sciences of the United States of America 108: 2480–2485.
Staudt V, Bothur E, Klein M, Lingnau K, Reuter S, Grebe N, Gerlitzki B, Hoffmann M, Ulges A, Taube C, Dehzad N, Becker M, Stassen M, Steinborn A, Lohoff M, Schild H, Schmitt E & Bopp T (2010) Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 33: 192–202
Bopp T, Becker C, Klein M, Klein-Hessling S, Palmetshofer A, Serfling E, Heib V, Becker M, Kubach J, Schmitt S, Stoll S, Schild H, Staege MS, Stassen M, Jonuleit H & Schmitt E (2007) Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J. Exp. Med. 204: 1303–1310
Bopp T, Palmetshofer A, Serfling E, Heib V, Schmitt S, Richter C, Klein M, Schild H, Schmitt E & Stassen M (2005) NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells. J. Exp. Med. 201: 181–187