Biology (Diploma), Johannes Gutenberg University Mainz
Scientific Degrees
Habilitation
Venia legendi for Immunology, Institute for Immunology at the University Medical Center of the Johannes Gutenberg University Mainz, 1997, E. Rüde
Doctoral thesis
"magna cum laude", Institute for Immunology at the University Medical Center of the Johannes Gutenberg University Mainz, 1986, E. Rüde
Professional Career
2011 - present
W2 Professor for "Cellular immunology", Institute for Immunology at the University Medical Center of the Johannes Gutenberg University Mainz
2003 - present
Deputy head, Institute for Immunology at the University Medical Center of the Johannes Gutenberg University Mainz
1999 - 2003
Acting head, Institute for Immunology at the University Medical Center of the Johannes Gutenberg University Mainz
1986 - 1999
Postdoctoral Fellow, Institute for ImmunologyInstitute for Immunology at the University Medical Center of the Johannes Gutenberg University Mainz, Prof. E. Rüde
Honours and Other Activities
2013 - 2014
Speaker of the "Transregional Collaborative Research Center (TRR) 52: Transcriptional programming of individual T cell subsets"
2008 - 2012
Deputy Speaker of the "Transregional Collaborative Research Center (TRR) 52: Transcriptional programming of individual T cell subsets"
2007 - present
Member of the executive board of the of the "Forschungszentrum für Immuntherapie" (FZI) at the Johannes Gutenberg University Mainz
1997 - present
Lecturer, Institute for Immunology at the University Medical Center of the Johannes Gutenberg University
Selected Publications
Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Brühl T-J, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reißig S, Haben I, Zipp F, Waisman A, et al. (2015) Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. Nat. Immunol. 16: 267–275. *) Authors contributed equally
Huang LR, Wohlleber D, Reisinger F, Jenne CN, Cheng RL, Abdullah Z, Schildberg FA, Odenthal M, Dienes HP, van Rooijen N, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwalder M, Knolle PA (2013) Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol. 14(6):574-83
Staudt V, Bothur E, Klein M, Lingnau K, Reuter S, Grebe N, Gerlitzki B, Hoffmann M, Ulges A, Taube C, Dehzad N, Becker M, Stassen M, Steinborn A, Lohoff M, Schild H, Schmitt E* & Bopp T* (2010) Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 33: 192–202. *) contributed equally
Bopp T, Becker C, Klein M, Klein-Hessling S, Palmetshofer A, Serfling E, Heib V, Becker M, Kubach J, Schmitt S, Stoll S, Schild H, Staege MS, Stassen M, Jonuleit H & Schmitt E (2007) Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J. Exp. Med. 204: 1303–1310
Bopp T, Palmetshofer A, Serfling E, Heib V, Schmitt S, Richter C, Klein M, Schild H, Schmitt E* & Stassen M* (2005) NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells. J. Exp. Med. 201: 181–187. *) contributed equally
Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J & Enk, AH (2002) Infectious tolerance: Human CD25+ regulatory T cells convey suppressor activity to conventional CD4+ T helper cells. J. Exp. Med. 196(2):255-60.
Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J & Enk A (2001) Identification and functional characterization of human CD4+CD25+ T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193:1285-1294
Jonuleit* H, Schmitt E*, Schuler G, Knop J, & Enk A. Induction of human IL-10-producing, non-proliferating CD4+ T cells with regulatory properties by repetitive stimulation with allogeneic immature dendritic cells. (2000) J. Exp. Med. 192:1213-1222. *) contributed equally.
Schmitt E, Germann T, Goedert S, Hoehn P, Huels C, Koelsch S, Kühn R, Müller W, Palm N & Rüde E (1994) IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-ß and IL-4, and is inhibited by IFN-γ. J. Immunol. 153:3989-3996
Schmitt E, van Brandwijk R, Van Snick J, Siebold B & Rüde, E (1989) TCGF III/P40 is produced by naive murine CD4+ T cells but is not a general T cell growth factor. Eur. J. Immunol. 19: 2167-2170