Visual Universitätsmedizin Mainz

Prof. Dr. med. Markus Munder

Prof. Dr. med. Munder
Funktionen: Oberarzt, Arbeitsgruppenleiter, UCT-Ambulanz
Qualifikationen: Facharzt für Innere Medizin, Schwerpunkt Hämatologie und Internistische Onkologie
06131 17-5948
06131 17-6678

Klinische und wissenschaftliche Schwerpunkte

  • Klinischer Schwerpunkt:
    Multiples Myelom
     
  • Wissenschaftliche Schwerpunkte:
    Immunregulation, Interaktion innates und adaptives Immunsystem, Tumorimmunologie, Tumormetabolismus, Arbeitsgruppe Munder 

Wissenschaftliche Auszeichnungen

  • 1999 Goedecke-Forschungspreis
  • 2003 Novartis-Stiftung für therapeutische Forschung

Publikationen (Auswahl)

  • Ioannidis, N. Shin, R. Conradi, M. Bros, S. Tenzer, M. Theobald, E.I. Closs, Munder M. Inhibition of arginase 1 liberates potent T cell immunostimulatory activity of human neutrophil granulocytes. Front Immunol. 2021; 11:617699. doi: 10.3389/fimmu.2020.617699.
  • Werner A, Pieh D, Echchannaoui H, Rupp J, Rajalingam K, Theobald M, Closs EI, Munder M. Cationic Amino Acid Transporter-1-Mediated Arginine Uptake Is Essential for Chronic Lymphocytic Leukemia Cell Proliferation and Viability Front Oncol. 2019; 9:1268. doi: 10.3389/fonc.2019.01268
  • Werner A, Koschke M, Leuchtner N, Luckner-Minden C, Habermeier A, Rupp J, Heinrich C, Conradi R, Closs EI, Munder M. Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression. Front Immunol. 2017;8:864. doi: 10.3389/fimmu.2017.00864 

  • Werner A, Amann E, Schnitzius V, Habermeier A, Luckner-Minden C, Leuchtner N, Rupp J, Closs EI, Munder M. Induced arginine transport via cationic amino acid transporter-1 is necessary for human T-cell proliferation. Eur J Immunol. 2016;46:92-103. 

  • Rath M, Müller I, Kropf P, Closs EI, Munder M. Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages. Front Immunol. 2014;5:532. 

  • Kapp K, Prüfer S, Michel C, Habermeier A, Luckner-Minden C, Giese T, Bomalaski J, Langhans C, Kropf P, Müller I, Closs EI, Radsak MP, Munder M. Granulocyte functions are independent of arginine availability. J Leukoc Biol. 2014;96:1047-53. 

  • Munder M, Engelhardt M, Knies MD, Medenhoff S, Wabnitz G, Luckner-Minden C, Feldmeyer N, Voss RH, Kropf P, Müller I, Conradi R, Samstag Y, Theobald M, Ho AD, Goldschmidt H, Hundemer M. Cytotoxicity of tumor antigen specific human T cells is unimpaired by arginine depletion. PLoS One. 2013;8(5):e63521. 

  • Oberlies J, Watzl C, Giese T, Luckner C, Kropf P, Müller I, Ho AD, Munder M. Regulation of NK cell function by human granulocyte arginase. J Immunol. 2009;182:5259-67. 

  • Munder M, Schneider H, Luckner C, Giese T, Langhans CD, Fuentes JM, Kropf P, Mueller I, Kolb A, Modolell M, Ho AD. Suppression of T cell functions by human granulocyte arginase. Blood. 2006;108:1627-34. 

  • Munder M, Mollinedo F, Calafat J, Canchado J, Gil-Lamaignere C, Fuentes JM, Luckner C, Doschko G, Soler G, Eichmann K, Müller FM, Ho AD, Goerner M, Modolell M. Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood. 2005;105:2549-56. 

  • Munder M, Bettelli E, Monney L, Slavik J, Nicholson LB, Kuchroo VK. Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand. J Exp Med. 2002;196:1151-62. 

  • Munder M, Mallo M, Eichmann K, Modolell M. Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation. J Exp Med. 1998;187:2103-8. 

  • Munder M, Eichmann K, Modolell M. Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J Immunol. 1998;160:5347-54.